The ongoing search for the ultimate travel handbag

I am working on the search for the ultimate travel handbag to take to my wedding down south in Colombia this summer. I have a couple of top contenders at the moment. This Gucci bag that I love. Major con is that it does not zip up at the top, but the material folds over and sort of closes that way. It is a really great size bag and could fit my water bottles, drugs, blackberry, camera, sunscreen etc. It is also held over the shoulder and tucked under your arm. Its cute but, still not 100% Sold though.